luke emia meaning. Leukopenia can indicate a variety of health complications, including serious infections, diseases, and cancer. luke emia meaning

 
 Leukopenia can indicate a variety of health complications, including serious infections, diseases, and cancerluke emia meaning  Therefore ALL is not staged like most other cancers

Fatigue. The average age of patients with T-PLL is 65 (the age range is 30 to 94 years). Acute myeloid leukemia (AML) is a type of acute leukemia. Pain or fullness in your stomach, which. Apheresis. Cancer can affect any part of the body, including the blood. Acute myeloid leukemia (AML) is the most common leukemia among the adult population and accounts for about 80% of all cases. Symptoms may include feeling tired, pale skin color, fever, easy bleeding or bruising, enlarged lymph nodes, or bone pain. Red blood cells carry oxygen through your body. . 5,000–10,000. Acute lymphocytic leukemia (ALL), also called acute lymphoblastic leukemia, is a cancer that starts from white blood cells called lymphocytes in the bone marrow. feel dizzy or lightheaded. There are several forms of the disease. Enlarge. AML affects myeloid cells, which are precursor cells that form into specific blood cells. It’s the most common type of cancer in children, but can also affect adults. Physiologic leukocytosis. If ALL spreads to the central nervous system,. There is the legacy of my twin sister and me continuing the mission of our mother’s work. These are scavenger cells that fight certain infections, destroy cancer cells, and help other white blood cells remove dead or damaged tissues. It slowly worsens over time, eventually leading to severe complications. 5. Swollen and/or painful stomach. The normal range of granulocytes is 1. Chemotherapy (chemo) is the main treatment for most types of AML, although. The symptoms of acute lymphocytic leukemia often develop rapidly over the course of days or a few weeks. AML staging. A low WBC count may be due to chemotherapy, a viral infection, a toxic reaction, or a process in the. This information is intended for people living in the United States who may have a primary language other than English. It happens when there are too many of the blood-forming cells called promyelocytes in the blood and bone marrow. Bone marrow is the spongy tissue inside bones where blood cells are made. It works by making the red blood cells more flexible. When ALL spreads to the chest, shortness of breath, and a cough may occur. Abdominal discomfort related to an enlarged spleen and liver called hepatosplenomegaly. Anxiety and depression: The emotional toll of facing end stage leukemia. -emia: or -hemia also -aemia or -haemia suff. A high platelet count is not always a serious concern. 227. Tissue damage from a burn injury or surgery. Bone pain. Many types of leukemia produce no obvious symptoms in the early stages. Therefore ALL is not staged like most other cancers. Predominant subtypes are acute myeloid leukemia (AML) and chronic myeloid leukemia (CML), involving the. About 8 out of 10 cases of ALL in children are B-cell ALLs. leucaemia. belly pain. Certain genetic abnormalities, such as Down syndrome. What is Luke short for? : r/AntiJokes. These are called intermediate soft tissue tumors. Leukemia is a malignant condition involving the excess production of immature or abnormal leukocytes, which eventually. By contrast, ALL increases the production of lymphocytes. Also referred to as hematology/oncology, or heme/onc, this field is focused on diagnosing, treating, and preventing blood, bone marrow, and lymphatic system cancers. Some people with MDS go on to develop acute myeloid leukemia (AML), so doctors sometimes used to view MDS as the first stage of AML. These leukemias start in early forms of white blood cells called lymphocytes. It occurs when the bone marrow beings to make blasts, cells that have not yet completely matured. Soft tissue sarcomas can develop in soft tissues like fat. In lymphoma, cancerous white blood cells form tumors in. These blasts normally develop into white. Pain in bones/joints. The samples are usually taken from the back of the pelvic (hip) bone, but sometimes other bones are. Summary. The pink awareness ribbon has become absolutely iconic. Children from 4 to 10 years. Terminal deoxynucleotidyl transferase ( TdT ), also known as DNA nucleotidylexotransferase ( DNTT) or terminal transferase, is a specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells,. Leukemia is a cancer of the blood or bone marrow, which produces blood cells. The FVRCP is a core vaccine for cats, meaning veterinary professionals agree that all cats. 4 million. But to make sure this research leads to safe and innovative. Cancer risk factors, screening tests, and treatments can vary from country to country. Hemoglobin is the substance that carries oxygen from the lungs, to the cells through the bloodstream. [ show] Treatment of acute myeloid leukemia (AML) is typically divided into 2 main phases: Remission induction (often just called induction) Consolidation (post-remission therapy) A third phase, known as maintenance, is sometimes used after consolidation. Acute lymphocytic leukemia is a type of acute leukemia. The Wiki on the Web. For personalized disease and treatment information, or to learn about clinical trials, contact one of The Leukemia & Lymphoma Society's (LLS's) Information Specialists at (800) 955-4572. A fast or unusual heartbeat. Shortness of breath. People with AML often have several non-specific (general) symptoms. Myelogenous (mai-uh-lOW-juh-nuhs) or myeloid leukemia develops from. This. The ABL1 gene encodes a non-receptor tyrosine kinase on chromosome 9, and BCR is a breakpoint. This stem cell goes through stages of development. It starts in your bone marrow, the soft inner parts of bones. It extends into nearby structures (for example, the chest wall in breast cancer). This causes the number of white blood cells in your body to increase. Only about 10% of leukemias are CML. There are no symptoms of high monocytes. It is a form of leukemia characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood. Enlarged lymph nodes such as in your neck or groin, under your arms, or above your collarbone. There are. Neutrophilic leukocytosis is an abnormally high number of neutrophils (a type of white blood cell ) in the blood. Both AML and ALL are acute types of leukemia. Fever. Symptoms and Causes | Treatment | Support. People with familial acute myeloid leukemia with mutated CEBPA have a shortage of white blood cells (leukopenia), leading to increased susceptibility to infections. For example: Risk factors for acute myeloid leukemia include smoking, exposure to high doses of radiation, certain blood disorders. Synonyms. So although lymphoma and leukemia each include issues with white blood cells, the effects can be different on the body. They can be classified as acute or chronic based on the rapidity of proliferation and myeloid or lymphoid based on the cell of origin. Acute lymphocytic leukemia (ALL), on the other hand, does not usually form tumors. Frequent or severe nosebleeds. Causes. This topic focuses on acute myeloid leukaemia (AML), which is an aggressive cancer of the monocyte or granulocyte. Thrombocytosis , or a high platelet count, is diagnosed when platelet levels are greater than 450,000 platelets per microliter of blood. Leukemia is a term for cancers of the blood cells. The spleen also stores white blood cells and platelets. “Preleukemia” was a term doctors previously used for myelodysplastic syndrome (MDS). leukemia meaning: 1. Many people with chronic lymphocytic leukemia have no symptoms at first. Depending on the techniques used, such as morphology by manual microscopy, immunohistochemistry, and flow cytometry, blasts are recognized and enumerated by different characteristics and. The most common symptom is a very high white blood cell count. 5–15. It moves to the dream with fish eggs a…. sore, swollen joints, particularly in the ankles and knees. Signs and symptoms of chronic myelogenous leukemia include weight loss and tiredness. Hairy cell leukemia might not cause symptoms. feel very tired – this is a very common symptom. The type of leukemia depends on the type of blood cell that becomes cancer and whether it grows quickly or slowly. 1510 eimí (the basic Greek verb which expresses being, i. AML is rare. Karloff. Luke Emia is a two-time character that appears in "Cody's New Friend!" and "Brooklyn Guy The Liar!". Feline leukemia virus (FeLV) is one of the most common infectious diseases in cats, affecting between 2 and 3% of all cats in the United States. The authors of the Mount Sinai/Brazilian hospitals study believe there is a chance that COVID may cause an abnormal immune response in the body that could trigger the cell mutations that cause. , nuclear radiation, radiation therapy) Smoking. تشمل العلامات والأعراض المعتادة لابيضاض الدم: الحمى أو القشعريرة. It's a type of cancer that starts in cells that become certain white blood cells (called lymphocytes) in the bone marrow. Definition. Morphologically, acute leukaemia is defined as the presence of > 20% blast cells in the bone marrow or peripheral blood. Stages III and IV are high risk. Leukemia. noun. This type of white blood cell is part of the immune system 's frontline defense, and having too many or too few can mean vastly different things. Bladder cancer. • Involves laboratory medicine, clinical hematology laboratory. These ranges can vary. 1016/S2352-3026 (21)00056-9. They can show small changes before problems get serious. poor appetite and weight loss. الأعراض. Myelodysplastic syndromes (MDSs) Myeloproliferative neoplasms (MPNs) Leukemia is a cancer that starts in the stem cells of the blood. Getting a diagnosis. The detection of chromosomal translocations can be important for the diagnosis of certain genetic diseases and disorders. 1510 /eimí ("is, am") – in the present tense, indicative mood – can be time-inclusive ("omnitemporal," like the Hebrew imperfect tense). High levels of eosinophils can indicate cancer (e. Simply put, it’s when your immune system isn’t working as well as it should to protect you from infection—or that your immune system can’t distinguish between normal and foreign cells. Instead, a variety of risk. [ show] Treatment of acute myeloid leukemia (AML) is typically divided into 2 main phases: Remission induction (often just called induction) Consolidation (post-remission therapy) A third phase, known as maintenance, is sometimes used after consolidation. The main treatment for most types of AML is chemotherapy, sometimes along with a targeted therapy drug. This occurs when the ANC is over 6,000 cells/mcL. There are different types of leukemia. High neutrophils and low lymphocytes together represent an elevated NLR ratio. malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer. Rapidly enlarging lymph nodes. 7 Not all sources, however, differentiate between male and female values; of these sources, values for both sexes. Swollen lymph nodes. Blame. These abnormal white blood cells are not able to fight infection and impair the ability of the bone marrow to produce red blood cells and platelets. Leukemia ( also spelled leukaemia and pronounced / luːˈkiːmiːə / [1] loo-KEE-mee-ə) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. word-forming element in pathology meaning "condition of the blood," Modern Latin combining form of Greek haima (genitive haimatos) "blood," a word of no established etymology (replacing the usual IE word, represented in Greek by ear; possibly from uncertain PIE root *sei-"to drip" (compare Old High German seim "virgin honey," Welsh. Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). An increase in the TLC count is known as leukocytosis, and it is a condition in which the body produces more WBCs. These can include: Weight loss. Male sex. Lymphocytes form part of the. 1510 (eimí), and its counterparts, (properly) convey "straight-forward" being (existence, i. According to the National Cancer Institute, B-cell acute lymphoblastic leukemia is the most common. A headache. What is Luke short for? Nothing, Luke was the name he was given at birth. • A type of cancer that starts in the bone marrow, where blood is produced. It is a form of leukemia characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood. [2] [8] Early on, there are typically no symptoms. Ans. Frequent or severe infections. 1 million. This cancer occurs primarily in older individuals, with a median age of diagnosis. Stage 0 is low risk. It’s the most common form of leukemia in adults. Swollen lymph nodes. Leukemia starts in blood-forming tissues such as the bone marrow. Symptoms. Acute leukaemias have a rapid onset and progression and are invariably fatal if left untreated. There are several types of leukemia, which are divided based mainly on whether the leukemia is acute (fast growing) or chronic (slower growing), and whether it starts in myeloid. These may be inherited, occur spontaneously, or arise due to certain environmental exposures. Fatigue. swollen, tender gums. Acute myeloid leukemia is caused by genetic abnormalities or changes. Polyclonal hypergammaglobulinaemia is most commonly caused by liver disease, immune dysregulation, or inflammation, but can also provide an important diagnostic clue. T-cell leukemia is an uncommon type of blood cell cancer that affects your white blood cells. 0 to 0. It is characterized by an extremely elevated blast cell count and symptoms of decreased tissue perfusion. Knowing the type of disease you have is key to choosing the right. It affects white blood cells, which your body needs to fight infection. There are different types of leukemia, which. When Leukemia cells cause swelling in the liver, kidneys, or spleen, these organs can press against the stomach. Normal is 32% to 36%. Carpal Tunnel Syndrome: Anger and frustration at life’s seeming injustices. easy. The type of leukemia depends on the type of blood cell that becomes cancer and whether it grows quickly or slowly. AML more commonly affects adults over 65 and has a low five-year survival rate. Different types of leukaemia are named according to: the type of blood cell which is affected. It’s the most common type of cancer in children, but can also affect adults. Leukemia is a type of cancer that affects the blood cells and bone marrow, a soft spongy tissue inside the bones where blood cells are made. He was chosen out of necessity, to answer Leia's call for help. [ loo-ke´me-ah] a progressive, malignant neoplasm of the blood-forming organs, marked by diffuse replacement of the bone marrow development of leukocytes and their precursors in the blood and bone marrow. Leukaemia (sometimes spelt as leukemia) is a cancer of the blood cells. Acute monocytic leukemia ( AMoL, or AML-M5) [2] is a type of acute myeloid leukemia. FLAGYL (metronidazole) tablets, 250 mg or 500 mg is an oral formulation of the synthetic nitroimidazole antimicrobial What is the use of Flagyl 200mg 400mg 500mg? - Flagyl has been used successfully in: septicaemia, bacteraemia, brain abscess, necrotising pneumonia, osteomyelitis, puerperal sepsis, pelvic abscess, pelvic cellulitisWBCs are normally high at birth, steadily decrease through infancy, then gradually decline until adulthood. Leukemia, a cancer of the blood-forming tissues characterized by a large increase in the numbers of white blood cells in the circulation or bone marrow. As an organization, The Leukemia & Lymphoma Society (LLS) has invested more than $1. CLL typically affects people aged 65 and. These symptoms include: fatigue. Leukemia can be either acute or chronic. Generally, leukemia refers to. More Information. In rare and more advanced cases, CLL can affect the central. Depending on the cause of the anemia, symptoms may include: Dizziness, lightheadness, or feeling like you are about to pass out. CLL is typically found when you get a blood test for another reason. Myelogenous (mai-uh-lOW-juh-nuhs) or myeloid leukemia develops from myeloid cells. These patients often have fever, poor appetite, and weight loss. A headache. This type of cancer usually gets worse quickly if it is not treated. Keeping track of your lab results lets your doctor take action as soon as your blood counts. Patients with blood cancers like leukemia are at risk for developing petechiae as a result of their cancer and as a side effect of their treatment. Putting it together. Acute Myeloid Leukemia. The Surveillance, Epidemiology, and End Results (SEER) Program provides information on cancer statistics in an effort to reduce the cancer burden among the U. Confusion: Leukemia can affect cognitive function, leading to confusion, disorientation, and difficulty concentrating or remembering things. A condition known as eosinophilia , high levels are described as mild (500 to 1,500 per microliter, ml, of blood), moderate (1,500 to 5,000 per ml), or severe (5,000 or more per ml). The spleen is located in the left upper quadrant of the abdomen, under the rib cage. Chronic lymphocytic leukemia. Later, non-painful lymph node swelling, feeling tired, fever, night sweats, or weight loss for no clear reason may occur. Contents Overview Symptoms and Causes. Low lgG can be caused by macroglobulinemia, also referred to as hyper-lgM syndromes. Leukemia Definitions and Meaning in English. , colon or lung), certain infections, and other health issues. It tends to have. whole fruits, such as apples or. It has a rapid. Leukemia is a type of blood cancer that affects the blood cells and bone marrow, a tissue inside bones where blood cells and platelets are made. [2] Later, non-painful lymph node swelling, feeling tired, fever, night sweats, or weight loss for no clear reason may occur. A decreased number of red blood cells (anemia) can lead to pallor and fatigue, while a decreased number of functional white blood cells (neutropenia) predispose affected individuals to infections. Chronic myeloid leukaemia (CML) is a type of cancer that affects the blood and bone marrow. Read more on Leukaemia Foundation website. bleeding and swollen gums. Abnormally low neutrophil count (neutropenia) as well as a high lymphocyte count (lymphocytosis) can be the result of viral infection or an indication of the adult-onset form of cyclic neutropenia, certain lymphoproliferative disorders like lymphomas and leukemias or certain autoimmune diseases. In the latest Sidemen Sunday video, Who wants to be a Millionaire 2, Harry did Callux dirt, very dirty 😭Subscribe to the channel for more Sidemen clipsPh-Positive Acute Lymphoblastic Leukemia Until recently, Ph-positive ALL was very aggressive and difficult to treat. without explicit limits). These stem cells are located in the bone marrow (the spongy. Leukemia is a malignant proliferation of white blood cell precursors in bone marrow or lymph tissue and their accumulation in peripheral blood, bone marrow, and body tissues. It is cancer that affects white blood cells known as B-cell lymphoblasts. Some of the most common causes of low platelets include an autoimmune disease called idiopathic thrombocytopenic purpura (ITP), leukemia, infection, nutritional deficiencies, pregnancy, and certain medications. AML causes the body to produce too many myeloblasts, platelets, and red blood cells. It is included in a routine blood panel known as a complete blood count (CBC). The word Leukemia comes from the Greek leukos which means "white" and aima which means "blood". The phases are based on how much the CML has grown or spread: Chronic phase, where less than 10% of cells in the blood and bone marrow are blast cells (leukemia cells). Blood samples for ALL tests are generally taken from a vein in the arm. If you have leukaemia your body makes some abnormal blood cells. fevers with no other symptoms. A relapse is when cancer comes back after treatment. It usually develops very slowly and does not always need to be treated straight away. To diagnose hairy cell leukemia, your health care provider may recommend: Physical exam. Frequent infections. People are often diagnosed with leukemia when their doctor finds abnormal blood counts during a routine physical exam. Swollen lymph nodes in your neck, armpits, stomach, or groin; lymph nodes are pea-sized glands in these and other areas of your body. Causes include compensated blood loss or hemolysis and hypoxia. Doctors base leukemia staging on the amount of cancerous white blood cells in the body. Fever. leukaemia definition: a serious disease in which the body produces too many white blood cells. Leukemia. These abnormal white blood cells are not able to fight infection and impair the ability of the bone marrow to produce red blood cells and platelets. CML is a clonal bone marrow stem cell disorder in which a proliferation of. Only the context indicates. It is more common in children than in adults. Infections. Chronic leukemia develops slowly and may need management over many years. Symptoms occur as the normal cells fail to perform their tasks, leading to infections and pain. Leukemia is cancer that starts in the bone marrow. “I can control my attitude, my exercise and my food,” he said. This might be followed by a stem cell transplant. Asparaginase Erwinia Chrysanthemi (Recombinant)-rywn. On this page. In adults, blood cells are formed in the bone marrow, by a process that is known as haematopoiesis. Formerly also leucemia. At levels below 1,000, you are at an increased risk of infection. e. These cells can grow and. Ans. This serious complication may also result in shortness of breath and other symptoms, such as: anxiety. It is called "smoldering" because it doesn't produce symptoms, but also doesn't resolve. This can lead to symptoms such as headaches, trouble concentrating, weakness, seizures, vomiting, problems with balance, and blurred vision. Abnormally high or low levels of MCH, as determined by blood testing, can be an. Symptoms may include bleeding and bruising, bone pain, fatigue, fever, and an increased risk of. Viral or bacterial infections. It is the name given to a group of leukaemias that develop in the myeloid cell line in the bone marrow. Bone marrow samples are obtained from 2 tests that are usually done at the same time: Bone marrow aspiration. Fever. • Symptoms include fever, chills, fatigue, weakness, weight loss, bone and joint pain, anemia. It is accompanied by a reduced number of erythrocytes and blood platelets, resulting in anemia and increased susceptibility to. • Process takes two to four hours and is similar to a regular blood donation. 15 U. On this page. Colors: Blue, marigold, and purple. The disease is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARA) gene and is. High levels of neutrophils may indicate a severe infection or stress on the body. By contrast, ALL increases the production of lymphocytes. cancer of the blood, leucaemia, leukaemia. These ranges are based on the cell counts of healthy people of similar age and sex. Leukemia and lymphoma are both forms of blood cancer, but they affect the body in different ways. swollen lymph nodes (swollen glands) in the neck, groin, or elsewhere. Leukemia is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. In CLL, the leukemia cells often build up slowly. called also aleukemic myelosis. As an acute leukemia, ALL progresses rapidly and is typically fatal. It affects the same organs of the lymphatic system (thymus, bone marrow, lymph nodes, spleen). : a disease of cats caused by the feline leukemia virus, characterized by leukemia and lymphoma, and often resulting in death. Eric J Zhao Catherine V Cheng. Hydroxyurea is used to prevent painful episodes and reduce the need for blood transfusions in patients with sickle cell anemia. Malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer. Symptoms. He hung out with Cody during that time and at the end of "Cody's New Friend!", he was later cured by God as it was revealed that he would later move to Vermont since he. Over time, the abnormal cells overtake the normal cells. cancer of the blood. Twitter; Wikitubia NetworkThe symptoms of chronic myeloid leukemia (CML) are often vague and are more often caused by other things. In contrast, leukostasis (also called symptomatic hyperleukocytosis) is a medical emergency most commonly seen in patients with acute myeloid leukemia or chronic myeloid leukemia in blast crisis. The values are higher in infants, ranging from 2 – 6%. 2) called the Philadelphia chromosome. Leukemia is a broad term for cancers of the blood cells. Learn more. However, high immature granulocyte levels can also be normal during pregnancy and in newborns. The spleen is an oval-shaped organ on the left side of the upper abdomen. Leukemia begins when healthy blood cells change and grow out of control. Loss of appetite. tiredness and/or anaemia (pale complexion, weakness and breathlessness) repeated infections (mouth sores, sore throat, fevers, sweats, coughing, frequent passing of urine with irritation, infected cuts and scratches, and boils) increased bruising and bleeding. Absolute monocytes per microliter of blood (mcL) Adults. Polycythemia vera. The main difference is that leukemia. Those white blood cells crowd out the red blood cells. Acute myelogenous leukemia (AML) is a cancer of the blood and bone marrow — the spongy tissue inside bones where blood cells are made. Leukemia cells ultimately occupy the bone marrow, replacing or suppressing the function of cells that develop into normal blood cells. When someone has this disease, the cells normally. If acute myeloid leukemia (AML) continues to grow or returns after one type of treatment, other types of treatment might still be helpful. Leukemia occurs due to a problem with blood cell production. The meaning of MYELOGENOUS LEUKEMIA is leukemia characterized by proliferation of myeloid tissue (as of the bone marrow and spleen) and an abnormal increase in the number of granulocytes, myelocytes, and myeloblasts in the circulating blood —called also myelocytic leukemia, myeloid leukemia. AML causes the body to produce too many myeloblasts, platelets, and red blood cells. Summary. Acute lymphocytic leukemia (ALL), on the other hand, does not usually form tumors. These can be further classified into sub-types. High IG counts suggest an infection or may point to a bone marrow condition. Candida: Feeling very scattered. Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood in order to replicate inside of a patient and to produce additional normal blood cells. CML is one of four main types of leukemia. It's called myelogenous (my-uh-LOHJ-uh-nus) leukemia because it affects a group of white blood cells called the myeloid. Hematologists and oncologists are specialists who treat people who have CML or other types of blood cancer. Chronic lymphocytic leukaemia cannot usually be cured, but it can be managed with treatment. It is cancer that affects white blood cells known as B-cell lymphoblasts. The fusion oncoprotein BCR-ABL1 defines CML. 5 – 8. A type of cancer that starts in the bone marrow, moves into the blood cells, and often metastasizes to other parts of the body including the liver, spleen, skin, brain, and spinal cord. It's not always. It may be autologous (the patient's own stem cells are used), allogeneic (the stem. Acute lymphocytic leukemia (ALL) is a cancer of the blood and bone marrow. To learn more about how cancers start and spread, see What Is Cancer?On this page. It starts in the bone marrow where blood cells are made. AML more commonly affects adults over 65 and has a low five-year survival rate. leukemia. Male sex. [ loo-ke´me-ah] a progressive, malignant neoplasm of the blood-forming organs, marked by diffuse replacement of the bone marrow development of leukocytes and their. 6 Cells multiply by dividing into two cells, making a new copy of the. It is characterized by clonal expansion of immature “blast cells” in the peripheral blood and bone marrow resulting in ineffective erythropoiesis and bone marrow failure. Splenomegaly refers to an enlarged spleen.